A recent study has cast light on the intricate mechanisms behind focal cortical dysplasia type I (FCD I), a significant cause of epilepsy that resists treatment. Researchers analyzed tissue samples from epilepsy patients and compared them with samples from patients with brain tumors (as a control) to get a clearer understanding of what goes wrong…

Abstract Methods to quantify cortical hyperexcitability are of enormous interest for mapping epileptic networks in patients with focal epilepsy. We hypothesize that, in the resting state, cortical hyperexcitability increases firing-rate correlations between neuronal populations within seizure onset zones (SOZs). This hypothesis predicts that in the gamma frequency band (40–200 Hz), amplitude envelope correlations (AECs), a relatively…

A new study has shed light on how genetic factors can help predict the likelihood of developing epilepsy, a neurological disorder that affects about 1% of the global population, particularly children and the elderly. The research focused on polygenic risk scores (PRSs), which measure the cumulative effect of multiple genetic variants on an individual’s risk…

The research article delves into the role of the GNAO1 gene, which encodes a protein called Gαo. Mutations in this gene can lead to severe developmental issues in children, including developmental delays, seizures, and involuntary movements. The researchers sought to understand how Gαo functions in the brain, particularly when its activity is disrupted. To do…