In a recent study, researchers examined a case of CDKL5 deficiency disorder (CDD) in an 11-year-old girl who exhibited severe symptoms related to this rare genetic condition. CDD is primarily characterized by early-onset epilepsy, along with various motor and cognitive challenges. The team utilized advanced genetic testing techniques to identify a novel mutation in the…

The article explores how patients who undergo anterior temporal lobe resection (ATLR) to treat drug-resistant temporal lobe epilepsy (TLE) experience changes in their language abilities over time. While it’s known that surgery can lead to language deficits, particularly when the left side of the brain is involved, the study dives deeper into how language functions can adapt and reorganize long after the surgery—up to about nine years later!

In a fascinating study, researchers dove into the brain’s intricate details to better understand why some epilepsy patients exhibit an increased T2 signal intensity (iT2SI) in a specific area of the brain known as the anterior temporal lobe white matter (aTLWM). This condition is often linked to hippocampal sclerosis, a common cause of temporal lobe epilepsy (TLE) that can significantly affect patients’ lives. By examining 23 patients—16 with the iT2SI and 7 with only hippocampal sclerosis—the team aimed to uncover the underlying histological changes associated with this signal in brain imaging.

A recent study has looked into the eating habits and food preferences of people with Dravet syndrome, a severe type of epilepsy that often starts in infancy. Researchers gathered information from 45 individuals with Dravet syndrome and compared them to a control group of 33 siblings of patients with various forms of epilepsy. Caregivers filled out questionnaires to provide insights into their loved ones’ food likes and eating behaviors, alongside answering open-ended questions about any challenges they face during mealtimes.

A recent study has delved into the intriguing relationship between blood-brain barrier dysfunction (BBBD) and epilepsy, particularly focusing on patients with drug-resistant epilepsy (DRE). The blood-brain barrier is a protective shield that controls what substances can enter the brain from the bloodstream. When this barrier becomes compromised, it can lead to a variety of neurological issues, and researchers wanted to see how this dysfunction might manifest in people with epilepsy compared to healthy individuals.

In a groundbreaking study, researchers developed a machine learning (ML) model designed to predict the initial onset of seizures in newborns suffering from hypoxic–ischemic encephalopathy (HIE). HIE is a serious condition that affects infants due to a lack of oxygen and blood flow to the brain, and seizures are a common complication. The model, dubbed Neo-GB, leverages both clinical data (like blood gas values and gestational age) and quantitative electroencephalogram (QEEG) features to assess seizure risk over time.

A recent study delves into the health challenges faced by Service Members and Veterans diagnosed with epilepsy—a condition that can come with a host of other medical issues. Researchers looked at data from the Veterans Health Administration, spanning from 2002 to 2018, to analyze the health trajectories of these individuals both before and after their epilepsy diagnosis.