Perampanel Shows Promise for Treating Severe Tremors

Source: Acta medica Philippina

Summary

Researchers studied the use of a medication called perampanel, which is already approved for treating seizures in epilepsy, to see if it could help people with severe tremors. They looked at various clinical studies published in the last ten years, focusing on those that specifically examined perampanel's effects on tremors. After reviewing 1,539 articles, they selected nine studies that met their criteria for quality assessment.

The key findings showed that low doses of perampanel (between 2-4 mg per day) were generally safe and well-tolerated by participants, with only minor side effects reported. Patients with essential tremors and primary orthostatic tremors experienced some improvement. However, the evidence is considered weak because the studies had small numbers of participants and many people dropped out before completing the trials.

This research is important because it suggests that perampanel might be a new option for treating tremors that don't respond to other treatments. However, the limitations of the studies mean that we cannot be sure about its effectiveness yet. More rigorous trials with larger groups of people are needed to confirm whether perampanel can reliably help those with tremors.

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