This hub covers drug-resistant epilepsy: When seizures aren’t controlled after trying two appropriate medicines. Research-backed next steps on diet therapies, devices, surgery evaluation, and safety.
If seizures aren’t controlled after two meds, it’s worth at least an evaluation at an epilepsy center.
Not necessarily. Some familiar consider it earlier depending on seizure type and goals.
Yes. Treatment response can change over time, and combinations/approaches matter.
Seizure frequency, triggers, sleep, missed meds, side effects, and rescue med use.
This article discusses a proposed way to personalize dosing of perampanel, a seizure medicine used in drug-resistant epilepsy.
Researchers looked at how long it took children with drug-resistant epilepsy to get a presurgical epilepsy evaluation after they were recognized as having drug-resistant epilepsy.
This report describes one infant with global developmental delay and refractory epilepsy associated with a TBC1D24 mutation.
This study looked at kidney stones and kidney calcium buildup in children with drug-resistant epilepsy who were treated with a ketogenic diet (KD) or a modified Atkins diet (MAD) at one hospital clinic.
This study followed 665 adults with drug-resistant focal epilepsy after an anti-seizure medicine was added or substituted.
This article is a conference summary, not a single clinical trial.
This paper is a review, not a new experiment.
This study looked at everyday functioning in children and teens with drug-resistant epilepsy who had palliative epilepsy surgery.
This paper was a systematic review, meaning the researchers gathered and summarized published reports about a rare genetic condition called ring chromosome 20 and the epilepsy linked to it.