This hub covers drug-resistant epilepsy: When seizures aren’t controlled after trying two appropriate medicines. Research-backed next steps on diet therapies, devices, surgery evaluation, and safety.
If seizures aren’t controlled after two meds, it’s worth at least an evaluation at an epilepsy center.
Not necessarily. Some familiar consider it earlier depending on seizure type and goals.
Yes. Treatment response can change over time, and combinations/approaches matter.
Seizure frequency, triggers, sleep, missed meds, side effects, and rescue med use.
Researchers retrospectively studied all patients younger than 19 years who underwent resective epilepsy surgery at Finland’s national pediatric epilepsy surgery center from 2002 through 2023.
This systematic review and meta-analysis compared two operations for drug-resistant mesial temporal lobe epilepsy: anterior temporal lobectomy (ATL) and selective amygdalohippocampectomy (SAH).
Researchers combined results from 19 studies involving 149 children with drug-resistant epilepsy who received deep brain stimulation (DBS).
This was a critical narrative review of research on combining several brain-imaging methods before surgery for drug-resistant epilepsy.
Researchers systematically reviewed 13 studies published from 1993 to 2024 about voice outcomes in people with epilepsy who had implanted vagus nerve stimulation (VNS).
Researchers systematically reviewed 14 randomized controlled trials involving 516 adults with epilepsy, including adults with drug-resistant focal epilepsy.
This systematic review and meta-analysis compared two procedures for drug-resistant epilepsy caused by MRI-positive focal cortical dysplasia type II (FCD II) or tuberous sclerosis complex (TSC).
This systematic review examined whether déjà vu, déjà vécu, dreamy states, and reminiscence during focal seizures can help identify the epileptogenic zone.
Researchers combined results from 48 studies involving 822 people with Lennox-Gastaut syndrome across 19 countries.