This hub covers drug-resistant epilepsy: When seizures aren’t controlled after trying two appropriate medicines. Research-backed next steps on diet therapies, devices, surgery evaluation, and safety.
If seizures aren’t controlled after two meds, it’s worth at least an evaluation at an epilepsy center.
Not necessarily. Some familiar consider it earlier depending on seizure type and goals.
Yes. Treatment response can change over time, and combinations/approaches matter.
Seizure frequency, triggers, sleep, missed meds, side effects, and rescue med use.
This report describes one child: a 12-year-old girl who presented at age 11 with daily absence seizures that did not respond to multiple antiseizure medicines.
This study examined how intellectual test scores changed over time in children and adolescents who had brain surgery for pharmacoresistant epilepsy.
This study looked at thalamic neuromodulation for children with drug-resistant epilepsy, meaning epilepsy that did not respond well to medicines.
This study looked at whether brain PET scan templates made for children, and matched to different ages, can help improve localization of the epileptogenic zone, the brain area where seizures start, in children with drug-resistant epilepsy.
This paper is a review, not a new experiment.
This article discusses a proposed way to personalize dosing of perampanel, a seizure medicine used in drug-resistant epilepsy.
Researchers looked at how long it took children with drug-resistant epilepsy to get a presurgical epilepsy evaluation after they were recognized as having drug-resistant epilepsy.
This report describes one infant with global developmental delay and refractory epilepsy associated with a TBC1D24 mutation.
This study looked at kidney stones and kidney calcium buildup in children with drug-resistant epilepsy who were treated with a ketogenic diet (KD) or a modified Atkins diet (MAD) at one hospital clinic.