New Insights on DEPDC5-Related Epilepsy for Better Care – illustration
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New Insights on DEPDC5-Related Epilepsy for Better Care

Source: Neurology

Summary

This study looked at a specific genetic cause of focal epilepsy called DEPDC5 variants, which are often linked to brain abnormalities. Researchers gathered data from 586 individuals with these variants, focusing on their experiences with epilepsy, including how often they developed seizures and how well treatments worked for them. The study included a diverse group of people, with many from Asian backgrounds, to better understand how this condition affects different populations.

The findings showed that by age 10, about 76% of children with DEPDC5 variants had developed epilepsy. Nearly half of the individuals had epilepsy that did not respond well to medication, and about 28% had brain abnormalities visible on MRI scans. The study also found that those who started having seizures at a younger age were more likely to have drug-resistant epilepsy and other challenges, such as intellectual disabilities. However, for those who underwent surgery for their epilepsy, a significant majority experienced positive outcomes.

These results are important because they provide clearer insights into how DEPDC5-related epilepsy affects individuals and highlight the need for early genetic testing and personalized treatment plans. The study emphasizes the potential benefits of considering surgery for children with early-onset epilepsy. However, it is important to note that the findings are based on existing data and may not cover all aspects of the condition, as they rely on the information available at the time of the study.

Original source

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