This hub covers drug-resistant epilepsy: When seizures aren’t controlled after trying two appropriate medicines. Research-backed next steps on diet therapies, devices, surgery evaluation, and safety.
If seizures aren’t controlled after two meds, it’s worth at least an evaluation at an epilepsy center.
Not necessarily. Some familiar consider it earlier depending on seizure type and goals.
Yes. Treatment response can change over time, and combinations/approaches matter.
Seizure frequency, triggers, sleep, missed meds, side effects, and rescue med use.
Researchers studied how the ketogenic diet (KD) affects the microbiota-gut-brain axis (MGBA) in people with drug-resistant epilepsy (DRE).
Researchers studied a patient with unusual movement problems linked to a change in the PRRT2 gene.
This study looked at how effective and safe four different medications—brivaracetam, cenobamate, lacosamide, and perampanel—are for adults with drug-resistant focal epilepsy.
Researchers studied how children with movement disorders, specifically those with severe muscle stiffness (known as hypertonia), are evaluated before undergoing neurosurgery.
Researchers studied 47 patients with drug-resistant temporal lobe epilepsy and hippocampal sclerosis who were undergoing surgery to help control their seizures.
This study looked at the effects of a medication called cenobamate on young adults with tuberous sclerosis complex (TSC) who have epilepsy that does not respond to other treatments.
This study focused on children with hemophagocytic lymphohistiocytosis (HLH), a serious condition that causes severe inflammation and can affect the brain.
Researchers studied the effectiveness of using common clinical characteristics to predict the results of genetic testing in adults with epilepsy.
Researchers studied early infantile epileptic encephalopathy (EIEE), a severe type of epilepsy that starts in infants and can lead to serious developmental issues.