This hub covers drug-resistant epilepsy: When seizures aren’t controlled after trying two appropriate medicines. Research-backed next steps on diet therapies, devices, surgery evaluation, and safety.
If seizures aren’t controlled after two meds, it’s worth at least an evaluation at an epilepsy center.
Not necessarily. Some familiar consider it earlier depending on seizure type and goals.
Yes. Treatment response can change over time, and combinations/approaches matter.
Seizure frequency, triggers, sleep, missed meds, side effects, and rescue med use.
This paper was a systematic review of randomized controlled trials on ketogenic diet therapies for people with drug-resistant epilepsy.
This study looked at people age 16 and older with idiopathic generalized epilepsy (IGE) who were admitted to one hospital’s epilepsy monitoring unit for inpatient video-EEG between 2008 and 2024.
Researchers looked for extremely fast brain-wave events in people with drug-resistant epilepsy.
This study looked at whether a less restrictive diet approach might help adults with drug-resistant epilepsy.
This study looked at whether magnetoencephalographic source imaging (MSI) adds diagnostic value for finding the brain area where seizures start in people with drug-resistant focal epilepsy.
This study looked at hemispherotomy, a surgery that disconnects one side of the brain, in children with drug-resistant epilepsy that developed after a traumatic brain injury.
This study asked a panel of 28 stakeholders from European Union countries and the UK to give their views about what “seizure freedom” should mean in epilepsy care and research, and why it matters.
This study looked at whether a brain signal called slow gamma activity in the anterior nucleus of the thalamus (ANT) might help indicate whether deep brain stimulation (DBS) is working for people with drug-resistant epilepsy.
This study looked at fenfluramine, a seizure medicine, in children and adults with developmental and epileptic encephalopathies (DEEs).