Positive Spike Waves Linked to Seizures and Developmental Delays
This study looked at the significance of positive spike wave (PSW) discharges in the brains of children aged 1 month to 19 years.
Drug-Resistant Epilepsy
This hub covers drug-resistant epilepsy: When seizures aren’t controlled after trying two appropriate medicines. Research-backed next steps on diet therapies, devices, surgery evaluation, and safety.
What you’ll find in this topic:
- Plain-language summaries of new epilepsy studies
- What the research means for real life
- Practical questions to ask your neurologist
- Related topics you can explore next
Drug-Resistant Epilepsy: What Families Usually Want to Know
- What “drug-resistant” means (and what it doesn’t)
- When to ask for an epilepsy center referral
- Treatment options beyond meds (diet, devices, surgery)
- How to think about risk, safety, and quality of life
Options Beyond Medication in Plain English
- Ketogenic diet / modified Atkins: Nutrition therapy that can reduce seizures
- VNS / RNS / DBS: Devices that modulate brain activity
- Surgery evaluations: Tests to see if seizures start in one removable area
- Rescue meds: Fast meds for clusters/prolonged seizures
- Sleep + triggers: Sometimes a meaningful lever (especially in teens)
Related Topics
Drug-Resistant Epilepsy FAQ
When should we consider surgery?
If seizures aren’t controlled after two meds, it’s worth at least an evaluation at an epilepsy center.
Is VNS a “last resort?”
Not necessarily. Some familiar consider it earlier depending on seizure type and goals.
Can seizures still improve later?
Yes. Treatment response can change over time, and combinations/approaches matter.
What should we track?
Seizure frequency, triggers, sleep, missed meds, side effects, and rescue med use.
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Microglia May Drive Inflammation and Iron Issues in Epilepsy
This study focused on understanding the role of microglia, a type of immune cell in the brain, in temporal lobe epilepsy (TLE), which is a common and hard-to-treat form of epilepsy.
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Comorbidities | Drug-Resistant Epilepsy | Epilepsy Research Summaries | New Studies | Safety & First Aid
Rare Condition Linked to Lamotrigine Requires Quick Action
Researchers studied two patients who developed a serious condition called haemophagocytic lymphohistiocytosis (HLH) after starting a medication called lamotrigine, which is often used to treat epilepsy.
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Improving Transition to Adult Epilepsy Care for Young Patients
This study looked at how young people with epilepsy move from pediatric to adult care at a single medical center.
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Genetic Mutations Linked to Drug Resistance in Pediatric Epilepsy
Researchers studied the relationship between specific genetic variations in the SCN1A gene and resistance to sodium valproate, a common epilepsy medication, in children.
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Drug-Resistant Epilepsy | Epilepsy Research Summaries | Genetics | New Studies | Pediatrics | Status Epilepticus
Comparing Two Drugs for Children With Severe Seizures
Researchers conducted a study to compare the effectiveness and safety of two medications, levetiracetam and sodium valproate, in treating children aged 1 to 16 years who were experiencing refractory generalized convulsive status epilepticus.
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Devices & Neuromodulation | Drug-Resistant Epilepsy | Epilepsy Research Summaries | Imaging & EEG | Lifestyle & Sleep | New Studies
Vagus Nerve Stimulation Device Linked to Heart Issues
Researchers examined a case involving a 41-year-old man who had epilepsy and was using a vagus nerve stimulation (VNS) device to help manage his seizures.
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First Diagnosis of FAME3 Using Advanced Genetic Sequencing
Researchers studied a rare genetic condition called Familial Adult Myoclonic Epilepsy type 3 (FAME3), which causes seizures and tremors.
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Comorbidities | Devices & Neuromodulation | Drug-Resistant Epilepsy | Epilepsy Research Summaries | New Studies | Safety & First Aid
Vagus Nerve Stimulation May Help Treat Immune Diseases
Researchers examined the use of vagus nerve stimulation (VNS) as a treatment for immune diseases, in addition to its established role in managing neurological conditions like epilepsy and depression.
